Laboratory of immunology and serology

Head of the Laboratory – Sashina Larisa Yuryevna, Doctor of Veterinary Sciences, Chief Scientific Associate, ORCID 0000-0001-6477-6156

Laboratory staff

The laboratory staff is working on

  • the study of the intensity of specific immunity to pathogens: infectious rhinotracheitis; parainfluenza-3; virus diarrhea – mucous membrane diseases (VD-BS); adenovirus infection, respiratory and syncytial infection in cattle; porcine reproductive and respiratory syndrome, porcine transmissible gastroenteritis, porcine circovirus type 2, classical swine fever, porcine parvovirus disease, actinobacillus pleuropneumonia, Mycoplasma hyopneumoniae, Chlamophila abortus;
  • the study of the hormonal status of farm animals in different physiological periods. Immunological research methods determine the quantitative serum content of estradiol, cortisol, progesterone and testosterone;
  • the study of the humoral link of immunity. As part of this research area​​, the employees determine the level of total immunoglobulins, as well as class A, M, G immunoglobulins. At the same time, the level of cytokines IL-1, IL-2, IL-4, IL-10, IFN-y, TNF-a, circulating immune complexes, bactericidal, complementary and lysozyme activities, cytokines are determined;
  • a comprehensive study of the cellular link of the immune system. The employees determine T- and B-lymphocytes, functional and metabolic activities of neutrophils (indicators of phagocytosis, spontaneous and induced bactericidal activity of segmented granulocytes);
  • the study of the comparative efficacy of immunomodulatory and therapeutic drugs used in veterinary practice. Methodical approaches to the prevention and treatment of immunodeficiency states in animals are being developed;
  • in order to ensure the biological safety of fodders, a quantitative determination of mycotoxins is carried out in the laboratory: Aflatoxin B1, Ochratoxin A, T-2 toxin, Zearalenone, deoxynivalenol (DON).

Research area

  1. Animal immunology, anti-infective immunity, immunopathology and immunodeficiencies. Immunological analysis in epizootology. Serology, seroprophylaxis and serotherapy of infectious animal diseases.
  2. Active specific prevention of infectious animal diseases, methods of vaccination. Means and methods of treatment and drug prevention of infectious animal diseases.
  3. Sources of mycotoxicoses, their diagnosis, treatment and prevention.